The Molecular Basis for Inhibition of Stemlike Cancer Cells by Salinomycin. Structure-Activity Relationships in Salinomycin: Cytotoxicity and Phenotype

IC50: 7.7, 13.7 and 10.4 μM for HepG2, SMMC-7721 and BEL-7402 cell line, respectively (after 24h treatment) Salinomycin (Sal), which is a polyether ionophore antibiotic from Streptomyces albus, has been proven to be able to kill different types of human

The results indicated that the stereoscopic configurations of the spiro C17 and C21 atoms as well as the benzoyl groups of O-20 on the rigid B/C/D spiro-ketal structures are crucial for biological activity and neural toxicity. 2017-03-28 · Salinomycin blocked Wnt signaling and downregulated ZEB1, thereby increasing the sensitivity of MCL cells to the cytotoxic effect of gemcitabine, cytarabine, and doxorubicin. 70 In combination with metformin, salinomycin was able to block TGFβ-induced EMT and inhibit EMT-induced cell migration in the two non-small-cell lung cancer cell lines A549 and HCC4006. 71 Salinomycin inhibited File:Salinomycin-structure.png.

The ionophore salinomycin exerts selective activity against cancer stem cells. Synthetic strategies for modification of the directly accessible functional groups of this structure are explored, and a set of activity domains are identified by biological assays. Salinomycin Hydroxamic Acids: Synthesis, Structure, and Biological Activity of Polyether Ionophore Hybrids Borgström, Björn LU ; Huang, Xiaoli LU ; Chygorin, Eduard ; Oredsson, Stina LU and Strand, Daniel LU ( 2016 ) In ACS Medicinal Chemistry Letters 7 (6) . p.635-640 Synthetic strategies for modification of each of the directly accessible functional groups of salinomycin are presented and the resulting library of analogues was investigated to establish structure–activity relationships, both with respect to cytotoxicity and phenotype selectivity in breast cancer cells. 20-O-Acylated derivatives stand out Salinomycin diastereoisomers and their benzoylated derivatives were synthesized and evaluated for both antiproliferative activity and neurotoxicity in vitro.The results indicated that the stereoscopic configurations of the spiro C17 and C21 atoms as well as the benzoyl groups of O-20 on the rigid B/C/D spiro-ketal structures are crucial for biological activity and neural toxicity. Crystal structure of salinomycin allyl amide acetonitrile solvate.

Salinomycin (sodium salt) is an antibacterial and coccidiostat compound that shows selective toxicity for the CSCs that exist as a subpopulation within HMLER breast cancer cells (IC 50 s = ~24 versus ~90 μM). 1 At 8 μM, salinomycin treatment of 4T1 and MCF-7-Ras breast cancer cell lines results in a ~2-fold and ~3-fold, respective reduction of CSCs relative to controls. 1 Treatment of 5 mg

Salinomycin sodium salt(55721-31-8) Reference standards for Pharmacological research. IC50: 7.7, 13.7 and 10.4 μM for HepG2, SMMC-7721 and BEL-7402 cell line, respectively (after 24h treatment)Salinomycin (Sal) sodi 2019-11-13 · Salinomycin counteracts the proliferation of uveal melanoma cells. a Chemical structure of salinomycin. b Uveal melanoma (UM) cells and ARPE-19 cells were treated with a gradient concentrations of salinomycin for 72 h, and the cell viability was measured by MTS assay.

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Sodium salinomycin.

20‐O‐Acylated derivatives stand out by exhibiting both improved selectivity and activity. 2016-04-28 2017-02-10 Salinomycin with antibacterial and anticoccidial activities is a commercial polyether polyketide widely used in animal husbandry as a food additive. Malonyl-CoA (MCoA), methylmalonyl-CoA (MMCoA), and ethylmalonyl-CoA (EMCoA) are used as extension units in its biosynthesis 2017-02-15 Salinomycin. 2 Product Results. | Match Criteria: Product Name, Property, Description. Empirical Formula (Hill Notation): C42H70O11.
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Cell membrane (also known as plasma membrane or plasmalemma) is a biological membrane that separates the contents of the cell from the outside environment. Functions.

CAS Number: 53003-10-4. S4526. from Streptomyces albus, ≥98% (HPLC) Sigma-Aldrich.
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Structure, properties, spectra, suppliers and links for: Salinomycin sodium.

Salinomycin is an antibacterial and coccidiostat ionophore therapeutic drug. Salinomycin has been shown by Piyush Gupta et al. of the Massachusetts Institute of Technology and the Broad Institute to kill breast cancer stem cells in mice at least 100 times more effectively than the anti-cancer drug paclitaxel. 2016-07-25 Identification.

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Biochemistry : the molecular basis of cell structure and function On the Breast Cancer Stem Cell Selectivity of Salinomycin and its Structural Analogues

Salinomycin-induced apoptosis is independent of tumor suppressor protein p53, caspase activation, the CD95/CD95 ligand system, and the proteasome. Salinomycin fails to induce apoptosis in normal human peripheral CD4+ T lymphocytes. Salinomycin (CHEBI:80025) has role animal growth promotant (CHEBI:82655) Salinomycin (CHEBI:80025) has role potassium ionophore (CHEBI:88227) Salinomycin (CHEBI:80025) is a polyketide (CHEBI:26188) Salinomycin (CHEBI:80025) is a spiroketal (CHEBI:72600) 13 Salinomycin Sodium O O O OH O H H O OH H O OH O HO H Salinomycin C42H70O11 MW: 751.0 CAS No.: 53003-10-4 (salinomycin), 55721-31-8 (salinomycin Na) [Summary of salinomycin sodium] Salinomycin is a polyether antibiotic obtained by the incubation of Streptomyces albus and has the chemical structure shown above. PDF | Salinomycin diastereoisomers and their benzoylated derivatives were synthesized and evaluated with both antiproliferative activities and | Find, read and cite all the research you need on IC50: 7.7, 13.7 and 10.4 μM for HepG2, SMMC-7721 and BEL-7402 cell line, respectively (after 24h treatment) Salinomycin (Sal), which is a polyether ionophore antibiotic from Streptomyces albus, has been proven to be able to kill different types of human The ionophore salinomycin selectively targets cancer stem cells. Synthetic strategies for modification of each of the directly accessible functional groups provide activity domains with respect to cy (A) Chemical structure of salinomycin. (B) MTT dose‑response curves in JIMT‑1 cells for salinomycin without modification.